heathcare study 22

This can be a breast most cancers stem cell line 1 ( BCSC1 ) from the newly established cell mannequin. Right here we are able to see the proteins keratin 5 in inexperienced and keratin eight in crimson, with the nucleus in blue. Credit score: Maurer Lab Scientists from the cluster of excellence BIOSS Centre for Organic Signalling Research on the College of Freiburg and the Freiburg College Medical Middle have proven that inhibiting the epigenetic regulator KDM4 would possibly supply a possible novel therapy possibility for breast most cancers sufferers. They used a newly established cell mannequin that permits scientists to isolate most cancers stem cells straight from affected person tumor. Utilizing this particular tradition system, they have been capable of check potential new most cancers medication. One among these, a novel inhibitor of the epigenetic regulator KDM4, co-developed within the lab of Prof. Schül...

Previous studies have shown that a high fat maternal diet during gestation and lactation has a long-term impact on the infant's gut microbiome (the community of bacteria living inside the human gut.) This study represents the first step in understanding whether breast milk contributes to this process. In this study, researchers found that specific changes to maternal diet in the same woman (changing fat versus carbohydrate consumption, or changing consumption of specific sugars), is associated with changes in both the milk microbiome and human milk oligosaccharide (a carbohydrate) composition. Given that these two components of breast milk have the potential to alter the gut microbiome of breast-feeding infants, the results of the study suggest that development of the infant gut microbiome may be affected in part by what the mother eats during breastfeeding. "Further studies are needed to delineate if specific changes in maternal diet during breast-feeding alter the inf...

Ion channels are tunnel-shaped passageways on the surface of neurons through which charged particles, or ions, can travel in and out of the cell. A deeper understanding of this brain-metabolism relationship could someday lead to new, better targeted treatments for obesity or diabetes, said lead author Dr. Kevin Williams, Assistant Professor of Internal Medicine at UT Southwestern and senior author of the study, published recently in  Cell Reports . "We found that an ion channel made up of TrpC5 (transient receptor potential cation 5) protein subunits is required for the proper regulation of basal metabolism and body weight," Dr. Williams said. In the mouse study, loss of TrpC5 caused types of nerve cells in the brain called Pomc neurons to become unresponsive to leptin or lorcaserin, resulting in increased body weight over time. The normally beneficial effect of lorcaserin on blood-sugar levels was also lost in mice deficient for TrpC5, the study showed. "As r...

A new study done at the University of Michigan Institute for Healthcare Policy and Innovation and published in the Annals of Internal Medicine draws this conclusion from an in-depth analysis of records from more than 5,600 senior citizens taking part in a long-term health study. The researchers looked at how the seniors' body mass index or BMI -- a measure of obesity -- related to end-of-life measures such as their use of hospice services, which provide supportive care to people in their final months of life. The higher someone's BMI, the less likely they were to enter hospice at all, the researchers found. And for those seniors who did use hospice services at the end of their lives, people with obesity spent fewer days in hospice than those with lower BMIs. About 60 percent of the seniors in the study died at home -- an experience that most Americans say they would choose for their own deaths. But that percentage dropped as BMI rose. The one thing that was higher amo...

Certain posts receive more responses than others, she has found. Grønning chose to analyse the diary entries of "Astrid," a very active user on the forum. "In 19 of 22 cases Astrid received positive responses when she posted confessions like, 'I've been eating sweets and drinking wine for several days.' The sociologist Erving Goffman uses the term 'saving face,' and from the responses it seems that the others in the forum know what it's like to be overweight, and they step in to help her save face," says Grønning. Supporting each other The results of the study have been published in Grønning's article, "Digital absolution: Confessional interaction in an online weight loss forum," which is part of her doctoral thesis on morbid obesity and the efforts and various processes associated with morbid obesity. She first heard about the national Norwegian weight loss forum when she interviewed people who had undergone weight ...

BPA is a chemical found in a variety of food containers, including polycarbonate plastic water bottles and can linings. BPA can interfere with the endocrine system by mimicking estrogen, one of the main sex hormones found in women. Research indicates BPA exposure is nearly universal. More than 90 percent of people tested in population studies had detectable levels of BPA and compounds produced when it is metabolized by the body in their urine. As of 2014, nearly 100 epidemiological studies had been published tying BPA to various health problems, according to the Society and IPEN's Introduction to Endocrine-Disrupting Chemicals. The new study found mice born to mothers exposed to BPA were less responsive to the hormone leptin, which is sometimes called the satiety hormone. Leptin helps inhibit the appetite by reducing hunger pangs when the body does not need energy. The hormone sends signals to the hypothalamus region of the brain to suppress the appetite. "Our findings...