New study reinforces the contribution of S6K1 kinase in obesity and aging
Previous studies by Drs. Thomas and Kozma had shown that S6K1 plays a critical role in fat tissue expansion by transcriptionally regulating the differentiation of mesenchymal stem cells (MSCs) into adipocytes (fat cells). As Dr. Thomas explained "In the meantime, Paul Fox contacted us proposing a possible connection between S6K1 and the glutamyl-prolyl-tRNA snythetase ( EPRS ), together we found that that S6K1 phosphorylation is required to release EPRS from its canonical role in protein synthesis to form the interferon γ inhibitor of translation ( GAIT ) complex, which blocks the translation of interferon regulated genes." "This change of function is key, since we also found that EPRS mediates the localization of the fatty acid transport protein 1 (FATP1) to the membrane, stimulating the uptake of long chain fatty acids," adds Dr. Kozma. "This confirmed a dual role of S6K1 in contributing to adiposity and aging. Indeed, mice with phospho-deficient EPRS pre...