New study reinforces the contribution of S6K1 kinase in obesity and aging

Previous studies by Drs. Thomas and Kozma had shown that S6K1 plays a critical role in fat tissue expansion by transcriptionally regulating the differentiation of mesenchymal stem cells (MSCs) into adipocytes (fat cells). As Dr. Thomas explained "In the meantime, Paul Fox contacted us proposing a possible connection between S6K1 and the glutamyl-prolyl-tRNA snythetase (EPRS), together we found that that S6K1 phosphorylation is required to release EPRS from its canonical role in protein synthesis to form the interferon γ inhibitor of translation (GAIT) complex, which blocks the translation of interferon regulated genes."
"This change of function is key, since we also found that EPRS mediates the localization of the fatty acid transport protein 1 (FATP1) to the membrane, stimulating the uptake of long chain fatty acids," adds Dr. Kozma. "This confirmed a dual role of S6K1 in contributing to adiposity and aging. Indeed, mice with phospho-deficient EPRS present the same physical characteristics (phenotype) as S6K1-deficient mice: low body weight, reduced adipose tissue mass, and increased lifespan. These results reinforce the concept that S6K1 may serve as a predictor of obesity or as a drug target to suppress obesity."
Dr. Kozma is currently collaborating with Dr. José Manuel Fernández-Real of the CIBERobn research group at the Hospital of Girona "Josep Trueta" and IDIBGI, in a project funded by La Marató de TV3 to obtain fat tissue samples to validate these results in humans and develop new biomarkers of adipose tissue expansion.


for more information visit our product website: Buy Vidalista Professional Pills Online 
Location: United States

Comments

Post a Comment

Popular posts from this blog

Prenatal bisphenol A exposure weakens body's fullness cues

BPA is a chemical found in a variety of food containers, including polycarbonate plastic water bottles and can linings. BPA can interfere with the endocrine system by mimicking estrogen, one of the main sex hormones found in women. Research indicates BPA exposure is nearly universal. More than 90 percent of people tested in population studies had detectable levels of BPA and compounds produced when it is metabolized by the body in their urine. As of 2014, nearly 100 epidemiological studies had been published tying BPA to various health problems, according to the Society and IPEN's Introduction to Endocrine-Disrupting Chemicals. The new study found mice born to mothers exposed to BPA were less responsive to the hormone leptin, which is sometimes called the satiety hormone. Leptin helps inhibit the appetite by reducing hunger pangs when the body does not need energy. The hormone sends signals to the hypothalamus region of the brain to suppress the appetite. "Our findings...
Read more

How changes in maternal diet impact human milk oligosaccharides and the milk microbio

Previous studies have shown that a high fat maternal diet during gestation and lactation has a long-term impact on the infant's gut microbiome (the community of bacteria living inside the human gut.) This study represents the first step in understanding whether breast milk contributes to this process. In this study, researchers found that specific changes to maternal diet in the same woman (changing fat versus carbohydrate consumption, or changing consumption of specific sugars), is associated with changes in both the milk microbiome and human milk oligosaccharide (a carbohydrate) composition. Given that these two components of breast milk have the potential to alter the gut microbiome of breast-feeding infants, the results of the study suggest that development of the infant gut microbiome may be affected in part by what the mother eats during breastfeeding. "Further studies are needed to delineate if specific changes in maternal diet during breast-feeding alter the inf...
Read more

The heavier the person, the lower the chance of getting hospice care or dying at home, study finds

A new study done at the University of Michigan Institute for Healthcare Policy and Innovation and published in the Annals of Internal Medicine draws this conclusion from an in-depth analysis of records from more than 5,600 senior citizens taking part in a long-term health study. The researchers looked at how the seniors' body mass index or BMI -- a measure of obesity -- related to end-of-life measures such as their use of hospice services, which provide supportive care to people in their final months of life. The higher someone's BMI, the less likely they were to enter hospice at all, the researchers found. And for those seniors who did use hospice services at the end of their lives, people with obesity spent fewer days in hospice than those with lower BMIs. About 60 percent of the seniors in the study died at home -- an experience that most Americans say they would choose for their own deaths. But that percentage dropped as BMI rose. The one thing that was higher amo...
Read more